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  • Title: Efficient synthesis of benzofuranones: N-heterocyclic carbene (NHC)/base-catalyzed hydroacylation-Stetter-rearrangement cascade.
    Author: Padmanaban M, Biju AT, Glorius F.
    Journal: Org Lett; 2011 Oct 21; 13(20):5624-7. PubMed ID: 21919536.
    Abstract:
    A N-heterocyclic carbene/base-catalyzed cascade reaction leading to the formation of functionalized benzofuranones is reported. The reaction proceeds via an intramolecular hydroacylation of unactivated alkynes followed by an intermolecular Stetter reaction and a base-catalyzed chromanone to benzofuranone rearrangement.
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