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  • Title: Polymorphism of the FcγRIIIa gene and post-treatment apical periodontitis.
    Author: Siqueira JF, Rôças IN, Provenzano JC, Guilherme BP.
    Journal: J Endod; 2011 Oct; 37(10):1345-8. PubMed ID: 21924179.
    Abstract:
    INTRODUCTION: Polymorphisms of genes encoding leukocyte surface receptors for the constant region of immunoglobulin G (FcγR) might influence the host response to infection and consequently affect the outcome of the endodontic treatment. This study investigated the association of FcγRIIIa gene (FcγRIIIA) polymorphism with post-treatment apical periodontitis in Brazilian subjects. METHODS: The study population consisted of 26 patients with post-treatment apical periodontitis and 43 subjects with root canal-treated teeth exhibiting healthy/healing periradicular tissues (controls). All teeth had apical periodontitis lesions at the time of treatment, which was completed at least 1 year previously. Saliva was collected from the participants; DNA was extracted and used for FcγRIIIA genotyping. RESULTS: No significant associations were found between any specific genotype of FcγRIIIA (P = .63) or allele (P = .76) and post-treatment apical periodontitis. Overall, the most prevalent allele in the study population was FcγRIIIA-F158 (68.8%). The genotype V/F was the most common among the population, occurring in 50.7% of the subjects. CONCLUSIONS: Data from the present study suggest that polymorphism in the FcγRIIIa does not influence the patient's response to endodontic treatment of teeth with apical periodontitis.
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