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  • Title: Mannan-binding lectin and mannan-binding lectin-associated serine protease 2 in acute pancreatitis.
    Author: Novovic S, Andersen AM, Ersbøll AK, Jorgensen LN, Nielsen HJ, Jensenius JC, Hansen MB.
    Journal: Pancreas; 2011 Oct; 40(7):1097-102. PubMed ID: 21926545.
    Abstract:
    OBJECTIVES: Complement activation may play a prominent role in acute pancreatitis (AP). Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) participate in complement activation. The objective of the present study was to evaluate the role of MBL and MASP-2 as markers in AP with regard to etiology, inflammatory activity, severity, and development of multiorgan failure. METHODS: Sixty patients with AP were included. All patients were diagnosed and treated according to a standardized regimen. Blood samples were obtained immediately on admission and again on days 1, 2, and 14. RESULTS: Both MBL (P < 0.001) and MASP-2 (P = 0.002) levels changed significantly over time, but without any significant relation to severity, multiorgan failure, or mortality. We found significantly higher levels of MBL (P = 0.04) in alcohol- than in gallstone-induced AP, but no significant difference in MASP-2 levels. CONCLUSIONS: The MBL and MASP-2 acted as acute-phase reactants, but overall, they were not markers for severity, multiorgan failure, nor for mortality in AP. Our results suggest that MBL and MASP-2 play only a minor role in the inflammatory response in AP.
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