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  • Title: Efficacy of a combined bezafibrate retard-colestyramine treatment in patients with hypercholesterolemia.
    Author: Fischer S, Hanefeld M, Lang PD, Fücker K, Bergmann S, Gehrisch S, Leonhardt W, Jaross W.
    Journal: Arzneimittelforschung; 1990 Apr; 40(4):469-72. PubMed ID: 2192717.
    Abstract:
    In a placebo-controlled randomized study the effect of combined bezafibrate-colestyramine therapy in comparison with monotherapy with both drugs was investigated. 47 patients with primary hypercholesterolemia received 400 mg bezafibrate (Cedur) retard/d, subsequently bezafibrate retard plus colestyramine (24 g/d) or colestyramine plus placebo in a double-blind fashion. The combination therapy was most effective (LDL decrease 36%, HDL-C increase 31%, apoprotein B decrease 28%), bezafibrate and colestyramine were equally effective with regard to LDL-C and apoprotein B, but only bezafibrate decreased triglycerides (-37%) and increased HDL-C (+24%). Bezafibrate was well-tolerated, but gastro-intestinal side-effects were frequent during therapy with colestyramine, and 16 patients tolerated only a reduced dosage of this drug. From the results presented it can be concluded that combined therapy with bezafibrate retard plus colestyramine is highly effective in the treatment of severe hypercholesterolemia.
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