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  • Title: Synthesis, biological evaluation and molecular docking of quinazoline-4(1H)-one derivatives as anti-inflammatory and analgesic agents.
    Author: Mohamed MS, Kamel MM, Kassem EM, Abotaleb N, Khedr M, Ahmed MF.
    Journal: Acta Pol Pharm; 2011; 68(5):665-75. PubMed ID: 21928711.
    Abstract:
    Two series of 2-phenyl-4(3H) quinazolinone derivatives have been synthesized. Most of the tested quinazolinone derivatives showed considerable potent anti-inflammatory and analgesic activity of superior GIT safety profile in experimental rats in comparing to indomethacin as reference drug. Compounds VIa, VIb were the most potent anti-inflammatory in experimental rats in comparing to indomethacin as reference drug. Docking study into COX-2 has been made for derivatives of anti-inflammatory activity.
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