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  • Title: Bioactive myrsinol diterpenoids from the roots of Euphorbia prolifera.
    Author: Xu J, Guo Y, Xie C, Li Y, Gao J, Zhang T, Hou W, Fang L, Gui L.
    Journal: J Nat Prod; 2011 Oct 28; 74(10):2224-30. PubMed ID: 21928782.
    Abstract:
    Ten myrsinol diterpenes, euphorbiaproliferins A-J (1-10), along with nine known analogues (11-19) were isolated from the roots of Euphorbia prolifera. Their structures were elucidated by spectroscopic data analysis (IR, ESIMS, HRESIMS, 1D and 2D NMR), and the structure of 1 was confirmed by X-ray crystallography. The diterpenes showed neuroprotective effects against MPP+-induced neuronal cell death in SH-SY5Y cells.
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