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  • Title: Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID.
    Author: Stringer KF, Ingles CJ, Greenblatt J.
    Journal: Nature; 1990 Jun 28; 345(6278):783-6. PubMed ID: 2193231.
    Abstract:
    The potent transactivation domain of the herpes simplex virion protein VP16 was used as a column ligand for affinity chromatography. VP16 binds strongly and highly selectively to the human and yeast TATA box-binding factors. Our results imply that the principal target for acidic activation domains is the TATA-box factor TFIID.
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