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  • Title: Leukemic phase of anaplastic lymphoma kinase positive, anaplastic large cell lymphoma.
    Author: Gadage VS, Subramanian PG, Galani KS, Sehgal KK, Johari SP, Ghogale VS, Badrinath Y, Ashok K, Gujral S.
    Journal: Indian J Pathol Microbiol; 2011; 54(3):599-602. PubMed ID: 21934233.
    Abstract:
    Anaplastic large cell lymphoma (ALCL) is a distinct type of CD30+ T/null-cell non-Hodgkin's lymphoma that frequently involves nodal and extranodal sites. The presence of leukemic phase in ALCL is extremely rare and occurs exclusively with ALK1-positive ALCL. We describe two patients with ALK1-positive ALCL who developed a leukemic phase with rapid progression of the disease. Immunophenotypic pattern assessed on peripheral blood by flow cytometry revealed CD45, CD30, and CD25 positivity in both cases but NPM-ALK1 was expressed in only one case. Both patients developed leukemic phase as a terminal event of the disease and we share the immunophenotypic features of both cases.
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