These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Preparation, characterization, and properties of fullerene-vinylpyrrolidone copolymers.
    Author: Jiang G, Li G.
    Journal: Biotechnol Prog; 2012; 28(1):215-22. PubMed ID: 21936064.
    Abstract:
    Water-soluble fullerene (C(60))-N-vinylpyrrolidone copolymers were prepared by the radical polymerization method. The structures of the copolymers were characterized by Fourier transform infrared, UV-Vis, (1)H NMR, (13)C NMR, gel permeation chromatography, thermogravimetric analyses, and scanning electron microscopy (SEM). The results presented show that C(60) and vinylpyrrolidone (VP) can be copolymerized under different conditions. With a constant benzoyl peroxide amount, C(60) contents in the copolymers increase with increasing initial C(60):VP reactant ratio. The assembly behavior of water-soluble C(60)-N-vinylpyrrolidone copolymers was investigated by SEM. The results show that the copolymers create morphology that is sphere-like. Fullerene-containing micro-/nano-sized copolymer fibers were prepared, for the first time, by electrospinning. The cytotoxicity to cancer cell lines of the copolymers was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and confocal laser scanning microscope. The results show that copolymers exhibit better cytotoxicity against HeLa cells and mouse osteogenic sarcoma cells (cytotoxicity of copolymers is better than that of fullerene complex). The mechanism of fullerene-VP copolymerization was investigated for the first time.
    [Abstract] [Full Text] [Related] [New Search]