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  • Title: Mouse lymphoma cells with mutations of cyclic AMP-dependent protein kinase.
    Author: Coffino P.
    Journal: Natl Cancer Inst Monogr; 1978 May; (48):377-80. PubMed ID: 219362.
    Abstract:
    Because S49 cells are senstivie to killing by cyclic AMP (cAMP), mutants can be selected which have a variety of defects in their ability to generate or respond to cAMP. One class of mutants, that with deficiencies in cAMP-dependent protein kinase, has been extensively characterized genetically and biochemically.
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