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  • Title: [Danger signals and inflammasomes in autoinflammatory and autoimmune diseases].
    Author: Bendtzen K.
    Journal: Ugeskr Laeger; 2011 Sep 19; 173(38):2340-3. PubMed ID: 21936977.
    Abstract:
    Cytoplasmic inflammasomes are formed through activation of pattern recognition receptors (PRR) of the innate immune system. Endogenous and exogenous danger signals, e.g. DNA- and RNA-fragments, urate- and cholesterol crystals, silica and asbestos, ß-amyloid, UV-light and skin irritants, may induce NOD-like receptor protein (NLRP)3 inflammasomes. These inflammasomes govern the induction of proinflammatory cytokines such as IL-1ß, IL-18 and IL-33. PRR and inflammasome dysfunctions may underly immunoinflammatory diseases such as gout and other arthritides, type 1 diabetes and arteriosclerosis.
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