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  • Title: Case for applying subnanosecond high-intensity, electrical pulses to biological cells.
    Author: Joshi RP, Hu Q.
    Journal: IEEE Trans Biomed Eng; 2011 Oct; 58(10):2860-6. PubMed ID: 21937300.
    Abstract:
    In this paper, model analysis into the time-dependent transmembrane potential at the outer cell membrane is presented, for applied high-intensity electric pulses having durations in the nanosecond range or smaller. It is argued that the frequency-dependent dielectric response of cell membranes could be used to advantage for stronger bioeffects by employing shorter pulses. Our model calculations predict faster transmembrane voltages and larger electroporation densities for a given external energy with pulse durations in the subnanosecond regime. This temporal regime would be used, for example, in the electrotherapy of mixed cell ensembles having different dielectric response properties.
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