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  • Title: [Role of polymorphous genes of xenobiotic biotransformation system in pathogenesis of occupational allergic dermatoses].
    Author: Kuz'mina LP, Izmerova NI, Koliaskina MM.
    Journal: Med Tr Prom Ekol; 2011; (7):17-23. PubMed ID: 21938920.
    Abstract:
    Studying genetic polymorphism of xenogiotics biotransformation system genes in patients with occupational allergic dermatoses, the authors revealed reliably higher percentage of polymorphous variants of CYP 1A1 *2C and EPHX1 A-415G genes, if compared with reference population. Combination of 3 polymorphous variants of xenobiotics biotransformation system genes (CYP 1A1, CYP3A4, EPHX1, GSTM1 and GSTT1) is characterized by earlier development, severe course and unfavorable prognosis of occupational skin condition.
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