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  • Title: One-pot synthesis of indole-fused scaffolds via gold-catalyzed tandem annulation reactions of 1,2-bis(alkynyl)-2-en-1-ones with indoles.
    Author: Xie X, Du X, Chen Y, Liu Y.
    Journal: J Org Chem; 2011 Nov 04; 76(21):9175-81. PubMed ID: 21939236.
    Abstract:
    The gold-catalyzed tandem cyclization of 1,2-bis(alkynyl)-2-en-1-ones with indoles offers an efficient and straightforward route to indole-fused polycyclic systems. The process is realized through a cascade carbonyl-yne cyclization/Friedel-Crafts/indole-yne cyclization sequence catalyzed by a single-pot catalyst of gold.
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