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  • Title: Neonatal herpes simplex virus.
    Author: Berardi A, Lugli L, Rossi C, Maria CL, Guidotti I, Gallo C, Ferrari F.
    Journal: J Matern Fetal Neonatal Med; 2011 Oct; 24 Suppl 1():88-90. PubMed ID: 21942600.
    Abstract:
    Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in utero, the transmission frequently occurs during delivery. The disease may be disseminated, localized to the central nervous system, or involving skin, eye and/or mouth. Mortality rates markedly decreased with high-dose antiviral treatment. Diagnosis of neonatal infection is based on viral isolation from ulcerated vesicles or by scarifying mucocutaneous lesions. Recently polymerase chain reaction plays a central role for both viral detection (skin, mucosal, cerebrospinal fluid samples) and response to therapy. Vertical transmission may be decreased by prophylactic antiviral treatment.
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