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  • Title: Direct synthesis of polysubstituted aluminoisoxazoles and pyrazoles by a metalative cyclization.
    Author: Jackowski O, Lecourt T, Micouin L.
    Journal: Org Lett; 2011 Oct 21; 13(20):5664-7. PubMed ID: 21942717.
    Abstract:
    Alumino-heteroles are obtained from simple precursors in a fully chemo- and regioselective manner by a metalative cyclization. The carbon-aluminum bond is still able to react further with several electrophiles, without the need of transmetalation. This synthetic route provides a novel entry to heterocyclic organoaluminum reagents as well as a straightforward access to 3,4,5-trisubstituted isoxazoles and 1,3,4,5-tetrasubstituted pyrazoles.
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