These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Endoscopic full-thickness resection in the colon by using a clip-and-cut technique: an animal study.
    Author: von Renteln D, Kratt T, Rösch T, Denzer UW, Schachschal G.
    Journal: Gastrointest Endosc; 2011 Nov; 74(5):1108-14. PubMed ID: 21944313.
    Abstract:
    BACKGROUND: Although endoscopic resection techniques have been established for definitive therapy of mucosal neoplasia, complete histopathological assessment or resection of subepithelial lesions is not reliably possible. OBJECTIVE: To overcome these limitations, a novel endoscopic full-thickness resection (EFTR) and closure technique was developed. DESIGN: Animal survival study. ANIMALS: Eight female domestic pigs. INTERVENTIONS: Two-centimeter artificial distal colonic lesions were created endoscopically. EFTR of the lesions was attempted using a prototype device, which consists of a large transparent plastic cap with a preloaded snare and a modified over-the-scope clip. After the procedure, half of the animals were killed after 7 days, and the other half after 28 days. MAIN OUTCOME MEASUREMENTS: Complete resection (all markings included in the specimen), technical success, complication rates, and wound healing on follow-up autopsy and histology. RESULTS: EFTR of healthy colonic tissue was possible in all cases; 2 additional clips had to be placed for complete closure in 1 case. In 1 animal, the preloaded closure failed, and the animal was prematurely killed. All other animals had an uneventful postoperative course. Necropsy and histopathological evaluation demonstrated well-healed resection sites with no evidence of intra-abdominal infection or inadvertent organ inclusion. LIMITATIONS: Animal model, resection of healthy tissue. CONCLUSION: This novel device allows for reliable full-thickness resection and closure of 2-cm specimens of the colonic wall in a single procedure as well as reliable wound healing of EFTR defects.
    [Abstract] [Full Text] [Related] [New Search]