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  • Title: Gangrene therapy and antisepsis before lister: the civil war contributions of Middleton Goldsmith of Louisville.
    Author: Trombold JM.
    Journal: Am Surg; 2011 Sep; 77(9):1138-43. PubMed ID: 21944621.
    Abstract:
    It is commonly accepted that Louis Pasteur is the father of microbiology and Joseph Lister is the father of antisepsis. Middleton Goldsmith, a surgeon in the Union Army during the American Civil War, meticulously studied hospital gangrene and developed a revolutionary treatment regimen. The cumulative Civil War hospital gangrene mortality was 45 per cent. Goldsmith's method, which he applied to over 330 cases, yielded a mortality under 3 per cent. His innovative work predated Pasteur and Lister, making his success truly remarkable and worthy of historical and surgical note.
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