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  • Title: Design of interior-functionalized fully acetylated dendrimers for anticancer drug delivery.
    Author: Hu J, Su Y, Zhang H, Xu T, Cheng Y.
    Journal: Biomaterials; 2011 Dec; 32(36):9950-9. PubMed ID: 21944725.
    Abstract:
    In this study, dendrimers was synthesized by introducing functional groups into the interior pockets of fully acetylated dendrimers. NMR techniques including COSY and 2D-NOESY revealed the molecular structures of the synthesized dendrimers and the encapsulation of guest molecule such as methotrexate within their interior pockets. The synthesized polymeric nanocarriers showed much lower cytotoxicity on two cell lines than cationic dendrimers, and exhibited better performance than fully acetylated dendrimers in the sustained release of methotrexate. The results provided a new strategy in the design of non-toxic dendrimers with high performance in the delivery of anti-cancer drugs for clinical applications.
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