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  • Title: [Effect of willed movement therapy on GFAP and SYP expression in rats with cerebral ischemia-reperfusion].
    Author: Hou DR, Shawuti S, Liu JF, Zhu HX, Deng JF, Hu ZY, Zhou J, Liu YX.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2011 Sep; 31(9):1543-6. PubMed ID: 21945762.
    Abstract:
    OBJECTIVE: To determine the effect of willed movement on the expression of glial fibrillary acidic protein (GFAP) and synaptophysin (SYP) in adult rats with cerebral ischemia-reperfusion, and explore the mechanism of willed movement in promoting nerve repair and regeneration. METHODS: Adult rat models of cerebral ischemia-reperfusion injury were established by middle cerebral artery occlusion (MCAO) for 2 h followed by a 24-h reperfusion. The models were then divided randomly into 3 groups, namely the model group, environmental modification (EM) group, and willed movement (WM) group. In each group, neurological deficits were evaluated at 3, 7 and 15 days after reperfusion. Immunohistochemistry and immunofluorescence assay were employed to examine the expression of GFAP and SYP in the brain tissue near the ischemic foci. RESULTS: The rats in WM group showed lessened neurological deficits at 15 days and lowered expression of GFAP and SYP at 7 and 15 days after reperfusion compared with the model and EM groups (P<0.05). No significant difference was found in the expression of GFAP or SYP between the model group and EM group at any time points. CONCLUSION: Willed movement can promote the functional recovery of neurological deficits following cerebral ischemia-reperfusion probably in relation to enhanced GFAP and SYP expressions in the ischemic brain tissues.
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