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  • Title: Establishment of highly metastatic variants of murine colon adenocarcinoma 26 under serum-free conditions.
    Author: Sugimoto Y, Oh-Hara T, Heike Y, Watanabe M, Nakatsuru Y, Ishikawa T, Tsuruo T.
    Journal: Int J Cancer; 1990 Jul 15; 46(1):118-24. PubMed ID: 2194981.
    Abstract:
    Tumor cell variants were established in vitro by treating a metastatic variant of murine colon adenocarcinoma 26 (P-26-select) in serum-free RPMI 1640 medium for 6 to 10 weeks. Five tumor cell lines were established from independent cultures and designated PS-1 to PS-5. The PS cells showed higher growth potential in vitro under serum-free or low-serum conditions than the parental P-26-select. In comparison to P-26-select, the PS cell lines possessed enhanced lung-colonizing ability after i.v. inoculation and metastasized spontaneously to the lung following s.c. inoculation into the flank or the right fore-footpads of BALB/c mice. Metastatic nodules were also observed in the liver. Spleens and livers of the tumor-bearing mice were enlarged mainly as a result of hematopoiesis, suggesting the production of CSF-like substance(s) by the tumor cells. The PS cells secreted increased amounts of putative autocrine growth factor(s) and CSF-like substance(s) in vitro. These characteristics might be related to the in vivo metastatic ability of the PS cells.
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