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  • Title: Carbamazepine differentially affects the pharmacokinetics of fexofenadine enantiomers.
    Author: Akamine Y, Miura M, Yasui-Furukori N, Kojima M, Uno T.
    Journal: Br J Clin Pharmacol; 2012 Mar; 73(3):478-81. PubMed ID: 21950458.
    Abstract:
    AIM: This aim of this study was to characterize the impact of the P-glycoprotein (P-gp) inducer, carbamazepine, on fexofenadine enantiomer pharmacokinetics. METHODS: Twelve healthy volunteers initially received a 60mg dose of fexofenadine alone. Subsequently, a 100mg dose of carbamazepine was administered three times daily (300mg day(-1) ), and on day 7, fexofenadine was co-administered. RESULTS: Carbamazepine significantly decreased the area under the plasma concentration-time curve and the amount excreted into the urine of (S)- and (R)-fexofenadine. The P-gp inducer showed a greater effect on the pharmacokinetic parameters of (S)-fexofenadine. CONCLUSION: This study indicates that carbamazepine may alter the pharmacokinetics of fexofenadine enantiomers.
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