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  • Title: The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore.
    Author: Courvalin JC, Lassoued K, Bartnik E, Blobel G, Wozniak RW.
    Journal: J Clin Invest; 1990 Jul; 86(1):279-85. PubMed ID: 2195063.
    Abstract:
    We have recently reported a new family of nuclear autoantibodies in a subset of patients with primary biliary cirrhosis. These antibodies bind to a nuclear envelope polypeptide(s) of approximately 200 kD, the exact identity of which was not established. In this study, we show that all of these autoantibodies are directed against a 210-kD integral membrane glycoprotein of the nuclear pore.
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