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  • Title: Development of highly cytotoxic and actin-depolymerizing biotin derivatives of aplyronine A.
    Author: Kita M, Hirayama Y, Sugiyama M, Kigoshi H.
    Journal: Angew Chem Int Ed Engl; 2011 Oct 10; 50(42):9871-4. PubMed ID: 21954061.
    Abstract:
    Tied up: a PEG-linked biotin derivative of marine macrolide aplyronine A (ApA) is shown to exhibit potent cytotoxicity and cause actin disassembly in tumor cells. This method of introducing a PEG linker at the end of the aliphatic tail should offer perspectives for developing and using versatile actin-targeting molecular probes. PEG=poly(ethylene glycol).
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