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  • Title: [Immunomodulator effect of silymarin therapy in chronic alcoholic liver diseases].
    Author: Deák G, Müzes G, Láng I, Niederland V, Nékám K, Gonzalez-Cabello R, Gergely P, Fehér J.
    Journal: Orv Hetil; 1990 Jun 17; 131(24):1291-2, 1295-6. PubMed ID: 2195425.
    Abstract:
    The effects of the hepatoprotective, antioxidant drug silymarin (Legalon) on some cellular immune parameters of patients with histologically proven chronic alcoholic liver disease were studied in a six month double blind study. The lectin induced proliferative activity of the lymphocytes got enhanced, the originally low T cell percentage and the originally high CD8+ cell percentage have been normalized, the antibody-dependent and natural cytotoxicity of the lymphocytes decreased during silymarin therapy. All these changes were significant, while in the placebo group no significant changes occurred, except for a moderate elevation of the T cell percentage. Thus, the immunomodulatory activity of silymarin might be involved in the hepatoprotective action of the drug and improves the depressed immunoreactivity of the patients.
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