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  • Title: [Effect of Eupolyphaga fibrinolytic protein on microvessel density and the expression of vascular endothelial growth factor in mice tumor].
    Author: Cao FC, Han YL, Chen B, Liu H, Ding H, Huang MX, Ye Y.
    Journal: Zhong Yao Cai; 2011 May; 34(5):676-9. PubMed ID: 21954551.
    Abstract:
    OBJECTIVE: To study the effect of Eupolyphaga fibrinolyric protein (EFP) on microvessel density (MVD) and the expression of vascular endthelial growth factor in transplantation S180 and H22 mice. METHODS: The MVD in tumor was measured with immunohistochemical SP method and the VEGF level in serum was measured with ELISA method. RESULTS: Compared with the control group, EFP could significantly reduce the microvessel density and decrease the expression of vascular endothelial growth factor. CONCLUSION: EFP has the effect of anti-angiogenesis.
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