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  • Title: [A combination of psoriasis vulgaris and nevus cell nevus--clinical, histopathologic and histochemical findings].
    Author: Wollina U, Schaarschmidt H, Henkel U, Roth H, Barta U, Hipler C.
    Journal: Z Hautkr; 1990 Apr; 65(4):381-2, 385-7. PubMed ID: 2195791.
    Abstract:
    In a study on 76 patients suffering from psoriasis, we found melanocytic nevi (MCN) within psoriatic lesions in 7%, and in perilesional areas of about 2 cm in 13% of the patients. Under magnification (operating microscope), we failed to detect any signs of psoriasis in both the epidermis covering the MCN and the adjacent epidermis. Histopathologically, 6 out of 7 MCN examined did not show any psoriatic alterations of the epidermis, and in all the 7 cases, the adjacent epidermis was free of psoriasis. Using unfixed frozen sections in histochemistry, we studied the lectin binding of FITC-labeled ConA and UEA I in 5 MCN. The epidermal reaction was comparable to that of psoriatic lesions. In contrast to psoriatic lesions, there was no staining of the spinous layer with a polyclonal antiserum against calmodulin, but only the staining of basal cells as in non-lesional psoriasis. We discuss possible 'protective' factors against psoriasis.
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