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  • Title: Efficient RNA synthesis by in vitro transcription of a triazole-modified DNA template.
    Author: el-Sagheer AH, Brown T.
    Journal: Chem Commun (Camb); 2011 Nov 28; 47(44):12057-8. PubMed ID: 21961113.
    Abstract:
    A DNA strand containing a triazole phosphodiester mimic is an efficient template for in vitro transcription. This is the first demonstration of transcription through a heavily modified DNA backbone linkage and it suggests that click-ligated DNA could be useful for the direct synthesis of biologically active RNA and proteins.
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