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  • Title: [Content of chaperon Hsp70 in dopaminergic neurons of the black substance increases in proteasome dysfunstion].
    Author: Pastukhov IuF, Ekimova IV, Guzhova IV, Romanova IV, Artiukhina ZE.
    Journal: Ross Fiziol Zh Im I M Sechenova; 2011 Jul; 97(7):649-60. PubMed ID: 21961290.
    Abstract:
    In Wistar rats, specific inhibitor UPS lactacystin induced degeneration of 24% of the dopaminergic neurons in the black substance. The work shows that a moderate weakening of the UPS function is characterized by an enhanced activity of the shaperon system. This process seems to restore and maintain population of the dopaminergic neurons.
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