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  • Title: [Dapsone for chronic skin lesions in 3 children suffering from Henoch-Schönlein vasculitis].
    Author: Mazille N, Lipsker D, Fischbach M.
    Journal: Arch Pediatr; 2011 Nov; 18(11):1201-4. PubMed ID: 21963373.
    Abstract:
    We describe 3 cases of chronic purpuric skin lesions in children suffering from systemic vasculitis: 3 children with Henoch-Schönlein purpura. Dapsone was introduced when skin lesions were recurrent, extensive, and persistent, due to its known ability to act as an anti-IgA and as an anticytotoxic agent against polynuclear neutrophils. Fast and complete but purely suspensive healing of skin lesions was noted. One child developed methemoglobinemia, a known side-effect of dapsone, highlighting the need for adequate prescription and follow-up.
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