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  • Title: Bactericidal activity of topical antiseptics and their gargles against Bordetella pertussis.
    Author: Suzuki T, Kataoka H, Ida T, Kamachi K, Mikuniya T.
    Journal: J Infect Chemother; 2012 Apr; 18(2):272-5. PubMed ID: 21968967.
    Abstract:
    Bordetella pertussis is the etiological agent of whooping cough, a common cause of respiratory illness in both children and adults. In the present study, we investigated the bactericidal activity of four antiseptics-povidone-iodine (PVP-I), benzethonium chloride (BEC), chlorhexidine gluconate (CHG) and benzalkonium chloride (BAC)-against B. pertussis ATCC9797 and clinical isolates. Among the topical antiseptics, PVP-I, BEC, and BAC, PVP-I and BAC in particular, showed high bactericidal activity, whereas CHG had low activity. PVP-I gargle also showed high bactericidal activity, similar to topical PVP-I. However, BEC gargle had low bactericidal activity. Our results indicate that topical PVP-I and BAC, and PVP-I gargle would be useful as effective antiseptics against B. pertussis.
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