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  • Title: [Hypovolemic-hemorrhagic shock. Pathophysiology and therapy].
    Author: Groh J, Dieterich HJ, Peter K.
    Journal: Infusionstherapie; 1990 Apr; 17 Suppl 2():4-8. PubMed ID: 2197225.
    Abstract:
    The common features of all different kinds of circulatory shock are a disturbance of the microcirculation and an imbalance between cellular oxygen demand and supply. The pathophysiology is discussed by the example of hypovolemic-hemorrhagic shock, including macrocirculation, humoral regulatory mechanisms, the role of vascular endothelium, and cellular dysfunction. The first aim of therapeutic efforts is the rapid restitution of a normal circulatory volume as a basic requirement for the normalisation of the microcirculation. Actual concepts of volume substitution and transfusion therapy are presented.
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