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  • Title: ICSH recommendations for the measurement of haemoglobin A2.
    Author: Stephens AD, Angastiniotis M, Baysal E, Chan V, Fucharoen S, Giordano PC, Hoyer JD, Mosca A, Wild B, International Council for the Standardisation of Haematology (ICSH).
    Journal: Int J Lab Hematol; 2012 Feb; 34(1):1-13. PubMed ID: 21974826.
    Abstract:
    Although DNA analysis is needed for characterization of the mutations that cause β-thalassaemia, measurement of the Hb A(2) is essential for the routine identification of people who are carriers of β-thalassaemia. The methods of quantitating Hb A(2) are described together with pitfalls in undertaking these laboratory tests with particular emphasis on automated high-performance liquid chromatography and capillary electrophoresis.
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