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  • Title: In vitro study on the inhibiting effect of different agents on the growth of Candida albicans on acrylic resin surfaces.
    Author: Spiechowicz E, Santarpia RP, Pollock JJ, Renner RP.
    Journal: Quintessence Int; 1990 Jan; 21(1):35-40. PubMed ID: 2197654.
    Abstract:
    This study evaluated at the in vitro level the antifungal effectiveness of nystatin, chlorhexidine, and a homologous histidine polypeptide on the surface of acrylic resin disks. The agents were used in a way that simulated storage of a denture by a denture wearer. Results indicated that pretreatment with poly-L-histidine was not protective against C albicans adherence and growth regardless of whether disks were stored in water or in the open air for the 8-hour period following yeast contamination. Chlorhexidine was totally effective in preventing C albicans attachment to, and growth on, the acrylic resin, even after a period of 8 days of turbidimetric monitoring. Pretreatment with Nystatin, followed by drying, was protective, yielding results similar to those obtained with chlorhexidine.
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