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  • Title: Application of antisera to interferon in studying oncogenic viruses.
    Author: Inglot AD, Oleszak E.
    Journal: Arch Immunol Ther Exp (Warsz); 1978; 26(1-6):529-36. PubMed ID: 219809.
    Abstract:
    Susceptibility of BALB/c mice to infection with Moloney sarcoma virus (MSV) and to Herpes simplex virus type 2 (HSV-2) was considerably increased by administration of sheep anti-mouse interferon (anti-IF) serum. The regression of the MSV-induced tumors was inhibited when the weanling (three-to-four-week-old) mice were injected with the anti-IF serum. Using the anti-IF serum it has been found that the antagonism between HSV-2 and Rauscher leukemia virus in the mouse is not mediated by interferon. It is suggested that interferon is an important factor controlling growth of virus and/or virus induced tumor cells in the mouse before it develops a strong immunological response.
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