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  • Title: POEMS syndrome with prominent acute axonal lesions.
    Author: Mathis S, Magy L, Kaboré R, Faugeras F, Richard L, Vallat JM.
    Journal: J Neurol Sci; 2012 Feb 15; 313(1-2):185-8. PubMed ID: 21982617.
    Abstract:
    Polyneuropathy is a common presenting component of POEMS syndrome whose symptoms are attributed to an overproduction of vascular endothelial growth factor (VEGF). We report two female patients with POEMS syndrome presenting as a severe predominantly axonal neuropathy. A nerve biopsy was performed for these patients; pathological data confirmed unusual numerous acute axonal lesions associated with other classical signs of POEMS syndrome. POEMS syndrome is usually associated with demyelinating neuropathy (and secondary axonal loss); however, prominent axonal neuropathy (with acute axonal lesions on nerve biopsy) can also be observed in this disease. These observations illustrate the heterogeneity of peripheral nervous system involvement in POEMS syndrome.
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