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  • Title: Comparative pathogenicity of six avian adenovirus isolants in the liver.
    Author: Lee KP, Henry NW, Rosenberger JK.
    Journal: Avian Dis; 1978; 22(4):610-9. PubMed ID: 219829.
    Abstract:
    The comparative pathogenicity of six avian adenovirus isolants for chickens was determined. The most virulent isolant was DPI-1, causing focal to massive hepatic necrosis with hemorrhage, while Tipton (Conn), Tipton (Purdue), GAL-1, and DPI-2 isolants were considered less pathogenic and produced only mild focal hepatic necrosis. The Indiana-C isolant was the least pathogenic and failed to produce any significant hepatic lesions. Intranuclear inclusions were observed in hepatocytes of all but the Indiana-C inoculated chickens on the third day postinoculation (PI), disappearing by the seventh day PI.
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