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  • Title: Synthesis of some novel D-glucuronic acid acetylated derivatives as potential anti-tumor agents.
    Author: El-Nezhawy AO, Adly FG, Eweas AF, Hanna AG, El-Kholy YM, El-Sayed SH, El-Naggar TB.
    Journal: Arch Pharm (Weinheim); 2011 Oct; 344(10):648-57. PubMed ID: 21984015.
    Abstract:
    A structurally diverse series of Δ(4,5) -uronamide derivatives have been chemically synthesized starting from D-glucuronic acid itself by means of acetylation, activation, amide bond formation and base-catalyzed elimination protocols. Structure elucidation for all products along with optimization of the synthetic steps is described. The synthesized compounds were evaluated for their in-vitro anti-tumor activity against MCF-7, TK-10 and UACC-62 cell lines. The compounds 5, 11, 13, 15 and 16 were the most active against TK-10 cell line. On the other hand, the most active compounds against the MCF-7 cell line were 11 and 15. However, compounds 5, 7, 11, 13, 15 and 16 were the most active against the UACC-62 cell line.
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