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  • Title: [Pathology, diagnostics, and treatment of Waldenström's macroglobulinaemia].
    Author: Holmström MO.
    Journal: Ugeskr Laeger; 2011 Oct 10; 173(41):2557-60. PubMed ID: 21985832.
    Abstract:
    Waldenström's macroglobulinaemia is a rare non-Hodgkin lymphoma with bone marrow involvement and serum immunoglobulin M monoclonal protein component. The most important risk factor is immunoglobulin M monoclonal gammopathy of undetermined significance. Clinical features vary but may include anaemia, neuropathy, infections and elevated serum viscosity. Diagnosis is confirmed by flow-cytometry made on bone marrow aspirate. Not all patients require treatment at diagnosis. The main therapeutic options include alkylating agents, nucleoside analogues and rituximab used in different combination regimens.
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