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  • Title: Synthesis of isochromene and related derivatives by rhodium-catalyzed oxidative coupling of benzyl and allyl alcohols with alkynes.
    Author: Morimoto K, Hirano K, Satoh T, Miura M.
    Journal: J Org Chem; 2011 Nov 18; 76(22):9548-51. PubMed ID: 21988500.
    Abstract:
    The straightforward synthesis of isochromene derivatives and related cyclic ethers is achieved by the rhodium-catalyzed oxidative coupling of α,α-disubstituted benzyl and allyl alcohols with alkynes. The hydroxy groups effectively act as the key function for the regioselective C-H bond cleavage.
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