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  • Title: Non-sterol structural probes of the lanosterol 14 alpha-demethylase from Saccharomyces cerevisiae.
    Author: Wright GD, Parent T, Honek JF.
    Journal: Biochim Biophys Acta; 1990 Aug 01; 1040(1):95-101. PubMed ID: 2198946.
    Abstract:
    A number of non-sterol iron-liganding molecules were used to probe the active site of the lanosterol 14 alpha-demethylase from Saccharomyces cerevisiae. Simple bi- and tricyclic aromatic amines were found to exhibit Type II binding spectra with the demethylase. Stereochemical and positional effects appear to play critical roles in the binding of these compounds to the demethylase. These compounds have been used to generate additional active-site structural information on this enzyme, currently a target for the development of new antifungal agents.
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