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  • Title: D-penicillamine in the treatment of eosinophilic fasciitis: case reports and review of the literature.
    Author: Manzini CU, Sebastiani M, Giuggioli D, Manfredi A, Colaci M, Cesinaro AM, Ferri C.
    Journal: Clin Rheumatol; 2012 Jan; 31(1):183-7. PubMed ID: 21989991.
    Abstract:
    Eosinophilic fasciitis (EF) is a rare disease characterized by symmetrical thickness and hardening of the skin, especially localized to forearms and thorax, with eosinophilia. Corticosteroids represent the first-line therapy, even if some patients are scarcely responsive and/or may develop important side effects due to long-term treatment. Here, we describe three cases of EF, two of them refractory to previous steroid therapy, successfully treated with D-penicillamine. The present clinical observations together with the updated review of the literature suggest usefulness of D-penicillamine in EF patients, as well as its potential steroid-sparing value.
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