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  • Title: Synthesis and biological activity of new bispyridinium salts of 4,4'-bispyridyl-5,5'-perfluoroalkyl-2,2'-bisoxazoles.
    Author: Martín-Cantalejo Y, Sáez B, Monterde MI, Murillo MT, Braña MF.
    Journal: Eur J Med Chem; 2011 Nov; 46(11):5662-7. PubMed ID: 21996467.
    Abstract:
    A series of bispyridinium compounds were synthesized by a short sequence of reactions from symmetric diamides. All compounds were tested for their antiproliferative activity against HT-29, a cell line derived from a human colon adenocarcinoma, and their inhibitory activity against choline kinase (ChoK), a novel anticancer molecular target already in clinical trials. Most of the compounds analyzed showed good antiproliferative activities, in the micromolar range, with the identification of promising lead molecules as a new family of potential inhibitors of ChoK.
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