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  • Title: [Levels of serum acylation-stimulating protein and C3 in children with primary nephrotic syndrome].
    Author: Wang JJ, Huang Y, Wu C, Xu YX, Wei YS, Zhao Y.
    Journal: Zhongguo Dang Dai Er Ke Za Zhi; 2011 Oct; 13(10):817-9. PubMed ID: 22000439.
    Abstract:
    OBJECTIVE: To study serum acylation-stimulating protein (ASP) and complement 3 (C3) levels and their relationship with blood lipids in children with primary nephrotic syndrome (PNS). METHODS: Blood samples were obtained from 35 PNS children with proteinuria, 25 children with PNS at remission and 35 body mass index-matched healthy children (control group). Fasting serum ASP, C3, albumin and blood lipids were measured. RESULTS: The serum ASP levels in the proteinuria group (101 ± 22 nmol/L) were significantly higher than those in the remission group (32 ± 8 nmol/L) and the control group (33 ± 8 nmol/L) (P<0.01). Serum C3 levels were not significantly different among the three groups. The serum concentrations of total cholesterol, triglyceride, low density lipoprotein and apolipoprotein B increased, in contrast, serum albumin level decreased significantly in the proteinuria group when compared with the remission and the control groups. Serum ASP levels were positively correlated with serum C3 (r=0.661; P<0.05) and triglyceride levels (r=0.354; P<0.05), whereas serum C3 levels were not correlated with serum triglyceride levels (r=0.319, P>0.05). CONCLUSIONS: The increased serum ASP level may be associated with a complemental mechanism against hyperlipidemia in children with PNS.
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