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  • Title: Design, synthesis and biological evaluation of substituted 11H-benzo[a]carbazole-5-carboxamides as novel antitumor agents.
    Author: Wang YQ, Li XH, He Q, Chen Y, Xie YY, Ding J, Miao ZH, Yang CH.
    Journal: Eur J Med Chem; 2011 Dec; 46(12):5878-84. PubMed ID: 22000922.
    Abstract:
    A series of novel 11H-benzo[a]carbazole-5-carboxamide derivatives were designed, synthesized and evaluated for their antitumor activity against human cancer A549 and HCT-116 cell lines. Most of the compounds showed potent antitumor activities, and compound 8 displayed remarkable in vitro and in vivo anticancer activity comparable to that of amonafide.
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