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  • Title: Islet cell antibodies as predictive markers for IDDM in children with high background incidence of disease.
    Author: Karjalainen JK.
    Journal: Diabetes; 1990 Sep; 39(9):1144-50. PubMed ID: 2200731.
    Abstract:
    To determine the prevalence and predictive value of islet cell antibodies (ICAs) for the development of insulin-dependent diabetes mellitus (IDDM) in 1212 Finnish children aged 3-18 yr, samples for ICA determination were taken in 1980, and subsequent analyses were performed in originally ICA+ children and in 296 initially ICA- children in 1983 and 1986. All 1212 subjects were followed for 8 yr for the development of IDDM. Fifty children (4.1%) were positive for conventional ICAs (IF-ICAs) in 1980 (range 3-80 Juvenile Diabetes Foundation units [JDF U]; median 30 JDF U), of which 12 (1.0%) had complement-fixing ICAs (CF-ICAs) in their serums (range 3-30 JDF U; median 8 JDF U). None were exclusively CF-ICA+. Boys were CF-ICA+ more often than girls (9 of 563 [1.6%] vs. 3 of 649 [0.5%], respectively; P less than 0.05). Over the next 6 yr, 4 of 39 subjects lost their IF-ICAs, and 4 of 12 lost their CF-ICAs without progressing to diabetes. The initial IF-ICA levels in these subjects were lower (range 3-8 JDF U; median 7 JDF U; P less than 0.05) than those in the persistent cases. In the initially ICA- subgroup (n = 296), 7 subjects (2.4%) later became IF-ICA+, and 4 (1.4%) became CF-ICA+. The levels of ICA in these subjects were lower than in the originally ICA+ ones (P less than 0.05), and 3 IF-ICA+ and 2 CF-ICA+ subjects again became ICA- before 1986.(ABSTRACT TRUNCATED AT 250 WORDS)
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