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  • Title: Antitumour and antioxidant activity of Scutia myrtina against Ehrlich ascites carcinoma in Swiss albino mice.
    Author: Kumar RS, Kumar KA, Murthy NV.
    Journal: Nat Prod Res; 2012; 26(16):1504-9. PubMed ID: 22007751.
    Abstract:
    The aim of this study is to investigate the antitumour and antioxidant activities of the ethanol extract of Scutia myrtina (EESM) against Ehrlich's ascites carcinoma (EAC) in mice. Twenty-four hours after tumour inoculation, EESM was administered at doses 100, 200 and 300 mg kg⁻¹ bodyweight/mice/day for 21 days. EESM caused a significant (p < 0.01) decrease in ascites volume, packed cell volume and viable cell count, and also prolonged the life span of EAC tumour-bearing mice. Haematological profiles reverted to near-normal levels in extract-treated mice (p < 0.01). EESM also produced protective effects by significantly decreasing the activity of serum enzymes and bilirubin and increasing the protein and uric acid levels (p < 0.05). EESM significantly (p < 0.05) decreased the levels of lipid peroxidation, while it significantly (p < 0.05) increased the levels of enzymatic and non-enzymatic antioxidants. The results indicate that EESM exhibited significant antitumour and antioxidant activities in EAC-bearing mice.
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