MEDLINE/PubMed Journal Browser Search

Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

Title: [Expression and prognostic value of VEGF-C and lymphangeogenesis in lung adenocarcinoma and squamous cell carcinoma].
Author: Dai X, Wang W, Shen-Tu Y, Zhang J.
Journal: Zhongguo Fei Ai Za Zhi; 2011 Oct; 14(10):774-9. PubMed ID: 22008106.
Abstract:
BACKGROUND AND OBJECTIVE: Vascular endothelial growth factor-C (VEGF-C), a member of the VEGF family, has been proven to be a relatively special VEGF. When binding to its receptor VEGFR-3, it activates lymphangiogenesis, which likely induces lymph node metastasis in tumors. The aim of this study is to characterize the expression and prognostic value of VEGF-C and lymphangiogenesis in lung adenocarcinoma and squamous cell carcinoma. METHODS: Through immunohistochemistry, the lymph vessel endothelial cells undergoing lymphangiogenesis were stained with podoplanin to detect the expression of VEGF-C and lymphangiogenesis in 98 cases with stage IIIa (N2) lung adenocarcinoma and squamous cell carcinoma. RESULTS: The expression rate of the VEGF-C was positively correlated with the lymphatic microvessel density (LMVD; r=0.783, P<0.01). The LMVD was remarkably higher in VEGF-C positive expression group than that in the VEGF-C negative expression group. The expression rate of VEGF-C and lymphangiogenesis in lung adenocarcinoma was significantly higher than that in lung squamous cell carcinoma (P<0.01). Kaplan-Meier analysis showed that the survival rates in patients with positive VEGF-C expression were significantly lower than those in patients with negative VEGF-C expression (P<0.05). CONCLUSIONS: Lymphangiogenesis rates are significantly higher in lung adenocarcinoma than that in squamous cell carcinoma. VEGF-C expression is an independent prognostic factor of stage IIIa (N2) lung adenocarcinoma and squamous cell carcinoma. 背景与目的: 血管内皮生长因子-C（vascular endothelial growth factor-C, VEGF-C）是VEGF家族的成员之一，且已被证明是相对特异的血管内皮生成因子，其与受体VEGFR-3结合后可激活淋巴管的生成，为肿瘤的淋巴结转移创造有利的条件。本研究旨在探讨VEGF-C和新生淋巴管在肺腺癌和鳞癌中的表达特点及其预后意义。方法: 以跨粘膜样受体蛋白（podoplanin）标记新生淋巴管内皮细胞，采用免疫组化方法检测98例Ⅲa（N2）期肺腺癌和鳞癌中VEGF-C和新生淋巴管的表达。结果: VEGF-C的表达率与微淋巴管密度（lymphatic microvessel density, LMVD）之间存在正相关（r=0.783, P < 0.01）。VEGF-C高表达组的LMVD大于低表达组（P < 0.01）。肺腺癌VEGF-C和新生淋巴管表达率明显高于肺鳞癌（P < 0.01）。VEGF-C阳性表达患者的生存率明显低于阴性患者（P < 0.05），VEGF-C是影响预后的独立因素。结论: Ⅲa（N2）期肺腺癌新生淋巴管的表达较鳞癌明显。VEGF-C是影响Ⅲa（N2）期肺腺癌和鳞癌患者预后的独立因素。

[Abstract] [Full Text] [Related] [New Search]