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  • Title: Atacamycins A-C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38.
    Author: Nachtigall J, Kulik A, Helaly S, Bull AT, Goodfellow M, Asenjo JA, Maier A, Wiese J, Imhoff JF, Süssmuth RD, Fiedler HP.
    Journal: J Antibiot (Tokyo); 2011 Dec; 64(12):775-80. PubMed ID: 22008702.
    Abstract:
    Three new 22-membered macrolactone antibiotics, atacamycins A-C, were produced by Streptomyces sp. C38, a strain isolated from a hyper-arid soil collected from the Atacama Desert in the north of Chile. The metabolites were discovered in our HPLC-diode array screening and isolated from the mycelium by extraction and chromatographic purification steps. The structures were determined by mass spectrometry and NMR experiments. Atacamycins A, B and C exhibited moderate inhibitory activities against the enzyme phosphodiesterase (PDE-4B2), whereas atacamycin A showed a moderate antiproliferative activity against adeno carcinoma and breast carcinoma cells.
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