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  • Title: Ameloblastic fibrosarcoma of the mandible: report of 2 chemosensitive pediatric cases.
    Author: Demoor-Goldschmidt C, Minard-Colin V, Cassagneau E, Supiot S, Oberlin O, D'hautuille C, Corradini N.
    Journal: J Pediatr Hematol Oncol; 2012 Mar; 34(2):e72-6. PubMed ID: 22009005.
    Abstract:
    Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumor. We report 2 pediatric cases of AFS from 2 different centers but reviewed by the same pathologist, which were unusual in that they were chemosensitive. Management was wide surgical resection, chemotherapy, and adjuvant radiotherapy. One case was a local AFS recurrence after incomplete surgery and the other was an AFS that was overlooked during earlier diagnosis of an ameloblastic fibroma. Both tumors responded very well to preoperative chemotherapy, with a reduction in tumor size and histologically proven decrease in viable tumor cell number. Both patients are well after 13 and 14 months of follow-up.
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